Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease

Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD).A previous study showed Activin A, whose transcription is upregulated by calcium influx via synaptic NMDARs, suppresses eNMDAR signaling.Therefore, we examined th

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Valuable Public Speaking Skills for Legal Professionals

In the constant endeavour to improve their public speaking skills, legal DSP professionals must be aware of the main aspects that they have to control and of the framework that they may use for that purpose.The elements of oral communication, politeness strategies, persuasion strategies, the main coordinates of verbal and nonverbal communication ar

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Characterization and efficacy against carbapenem-resistant Acinetobacter baumannii of a novel Friunavirus phage from sewage

Carbapenem-resistant Acinetobacter baumannii (CRAB) has become a new threat in recent years, owing to its rapidly increasing resistance to antibiotics and new effective therapies are needed to combat this pathogen.Phage therapy is considered to be the most promising alternative for treating CRAB infections.In this study, a novel phage, Ab_WF01, whi

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